Rahul Roy 

• Assistant Professor Chemical Engineering, IISc, Bangalore, India                 Sep 2012-Sep 2018

• Intermediate Fellow, Wellcome Trust - DBT India Alliance                             Sep 2013 - Sep 2018

• Associate Faculty, Molecular Biophysics Unit, IISc, Bangalore, India             Sep 2012-Sep 2018

• Research Associate, Sunney Xie Lab, Harvard University, Cambridge, MA    Jun 2011-Aug 2012

• Jane Coffin Childs Memorial Post Doctoral Fellow, Harvard University       Jun 2008- May 2011

• Taekjip Ha Lab, University of Illinois, Urbana-Champaign (UIUC), IL        Jun 2007 – Sept 2007

Graduate Research Assistant

• Taekjip Ha Lab, University of Illinois, Urbana-Champaign (UIUC), IL        Jun 2007 – Sept 2007

• Taekjip Ha Lab, University of Illinois, Urbana-Champaign (UIUC), IL         May 2002 - May 2007

Graduate Teaching Assistant

• Course Title: ‘Physical Biology: From Single Molecules to Systems Biology’ University of Illinois, Urbana-Champaign (UIUC), IL                                                              Jan 2006 - April 2006

•  Course Title: ‘Advanced Electronics Lab’  University of Illinois, Urbana-Champaign (UIUC), IL                                                                                                                                     Jan 2002 - April 2002

Visiting Student Research Fellow

Tate Institute for Fundamental Research (TIFR), Mumbai                               May 2000 - July 2000

Research Fellow

BREF-BioTEK Institute, Indian Institute of Technology (IIT), Kharagpur         May 1999 - July 1999

Various topics highlighting experimental techniques and modeling approaches in systems biology for problems ranging from molecular level to the multi-cellular level will be covered.

Topics: Properties of biomolecules, Biomolecular Forces, Single molecule experimental techniques, Molecular motors, Molecular heterogeneity, Self-organization, Enzyme kinetics, Modeling cellular reactions and processes, Fluctuations and noise in biology, Cellular variability, Biological networks, Modeling dynamics of bioprocesses and cellular signaling.

Instructor: Rahul Roy

Link for the course: CH 248 Molecular Systems Biology

Course Notes:

The course is intended for Masters and Research students. Undergraduates with sufficient background may approach the instructor regarding crediting the course. No prior knowledge of biology is needed but a non-biologist will have to self-educate. Basic grasp of calculus, linear algebra and programming skills in C or Matlab / Mathematica is recommended.

• Philip Nelson, Biological Physics: Energy, Information, Life, W. H. Freeman, 2007, ISBN-13: 978-0716798972.

• Edda Klipp, Wolfram Liebermeister, Christoph Wierling, Axel Kowald, Hans Lehrach, Ralf Herwig, Systems Biology, Wiley-Vch, 2009, ISBN: 978-3527318742.

• Uri Alon, An Introduction to Systems Biology: Design Principles of Biological Circuits, Chapman & Hall/CRC Mathematical & Computational Biology, 2006, ISBN: 978-1584886426.

• Basic concepts on structural basis for macromolecular recognition. Concept of charge in macromolecules, specific and non-specific recognition, symmetry in DNA-protein recognition, structural ensembles, co-operativity, specific examples, story of lambda, restriction enzyme recognition, t-RNA synthetase recognition, promoter-RNA polymerase interaction, inducers and repressors, action at a distance. Single molecule paradigm. Methods to follow nanobiology. DNA-protein recognition at the level of single molecules.

• Instructor: Dipankar Chatterji / Rahul Roy

Overview, review of background material. Differential and integral balances for homogeneous reactive systems. Ideal reactors: batch/CSTR/PFR. Uniqueness and multiplicity of steady states, heterogeneous reactions and reactors, non-ideal reactors.

Instructors: K Kesava Rao / Rahul Roy

• Aris R., Elementary Chemical Reactor Analysis, Prentice-Hall 1969.

• Schmidt, L.D., The Engineering of Chemical Reaction, Oxford, 1998.

• Froment G.F., Bischoff K.B., and Wilde, J.D., Chemical Reactor Analysis and Design, Wiley, 2011.

Origin of structural DNA nanotechnology; properties of DNA and other nucleic acids relevant to nanotechnology; design of branched DNA systems; DNA nanomechanical devices; DNA origami and DNA bricks; Forces and energetics in nanoscale; Thermodynamics of self-assembly formation; Experimental techniques to characterize DNA nanostructures including AFM, SEM, TEM; single molecule and fluorescence methods; gel electrophoresis; sequencing and radio-labelling assays; Application of DNA nanostructures in molecular computing; organizing and templating other nanomaterials; bio-sensing; nano-fabrication; cargo delivery; hybrid DNA nanomaterials. 

Instructor: Banani Chakraborty/ Rahul Roy

• DNA Nanotechnology: From structure to function /Fan, Chunhai /Springer

• Structural DNA nanotechnology / Seeman, Nadrian / Cambridge Uni. Press

• Articles / lecture notes provided by the instructor