Laboratory for NanoBiology

Our understanding of most biological processes comes from ensemble studies of the molecules carried out in a tube or using reporters in cells and organisms. Such mechanistic understanding of biological phenomena is complicated by

  • the heterogeneity among biomolecules (due to modifications or conformational dynamics) ,
  • the transient nature of interactions (activating action of molecule maybe limited to a fraction of its lifetime) and
  • the limits on detection of small number of molecules.

How do events taking place at the level of single molecule translate to biologically significant phenomena?

Our lab leads an interdisciplinary research program that aims to innovate and engineer technologies to help understand this basic question. We primarily focus on long-standing questions in infectious diseases caused by positive strand RNA viruses and pathogenic bacteria using single molecule detection, quantitative genomics and high-resolution imaging.

To learn more, please read our research interests.

Our laboratory is located in the Department of Chemical Engineering at the Indian Institute of Science, Bangalore, India. We are also associated with the Molecular Biophysics Unit and the Centre for BioSystems Science and Engineering at IISc. Directions to the lab can be found here.

Latest News

  • Jatin's first paper on using Fusible alloy for Microfluidic Impedance Cytometry is out in Microelectronic Engineering (05/2019)
  • Our work on smartphone based sensing of antibiotic kanamycin is accepted in RSC advances (02/2019)
  • Welcoming new lab members: Swastik Hedge (SRF) and Twinkle Gupta (External MS intern) to the lab (01/2019)
  • Satyaghosh wins the Zeeshan Khan Memorial award at the Bangalore Microscopy Course 2018 for his paper with Pradeep on pore forming toxin, Cytolysin A (09/2018)
Last Updated: 17th March 2019