Laboratory for NanoBiology

Our understanding of most biological processes comes from ensemble studies of the molecules carried out in a tube or using reporters in cells and organisms. Such mechanistic understanding of biological phenomena is complicated by

  • the heterogeneity among biomolecules (due to modifications or conformational dynamics) ,
  • the transient nature of interactions (activating action of molecule maybe limited to a fraction of its lifetime) and
  • the limits on detection of small number of molecules.

How do events taking place at the level of single molecule translate to biologically significant phenomena?

Our lab leads an interdisciplinary research program that aims to innovate and engineer technologies to help understand this basic question. We primarily focus on long-standing questions in infectious diseases caused by positive strand RNA viruses and pathogenic bacteria using single molecule detection, quantitative genomics and high-resolution imaging.

Such understanding of pathogen biology and host-pathogen interactions will help us design new drugs, vaccines and intervention strategies against several infectious diseases including Dengue.

To learn more, please read our research interests.

Our laboratory is located in the Department of Chemical Engineering at the Indian Institute of Science, Bangalore, India. We are also associated with the Molecular Biophysics Unit and the Centre for BioSystems Science and Engineering at IISc. Directions to the lab can be found here.

Latest Lab News

  • We welcome new members; Deepali Pathak (Research Associate), Rakhi Sharma (Project Assistant) and Neova Paul (Visiting Project student) to the lab (08/2019)
  • Saurabh Umrao, our third lab member submits his thesis! Congratulations to Saurabh as he joins Ernst & Young, Bangalore (06/2019)
  • Jatin Panwar, the first PhD candidate from the lab defends his thesis on single cell analysis with droplet microfluidics (06/2019) Congratulations and good luck as he heads to EMBL, Heidelberg for his post-doc!
  • Welcome to Twinkle Gupta and Tanvi Kaku (new research fellows joining the lab) (06/2019)

Latest Publications

  • Jatin's first paper on using Fusible alloy for Microfluidic Impedance Cytometry is out in Microelectronic Engineering (05/2019)
  • Our work on smartphone based sensing of antibiotic kanamycin is published in RSC advances (02/2019)
Last Updated: 17th March 2019