Nanobiology lab is selected to lead an inter-institutional grant to study the sero-prevalence of human pathogens in Karnataka
How do events taking place at the level of single molecule translate to biologically significant phenomena?
Our lab leads an interdisciplinary research program that aims to innovate and engineer technologies to help understand this basic question. We primarily focus on long-standing questions in infectious diseases caused by positive strand RNA viruses and pathogenic bacteria using single molecule detection, quantitative genomics and high-resolution imaging.
Such understanding of pathogen biology and host-pathogen interactions will help us design new drugs, vaccines and intervention strategies against several infectious diseases.
Our research is borne out of the need to alleviate the huge burden of infectious disease driving public health challenges. We also derive inspiration from the quintessential nanofactories a.k. a. microbes for how things work in the nano-regime.
Our research focuses on the following major themes
N Ronceray et al. , "Multiplexed lifetime imaging of single molecules with a gated single-photon camera" accepted in Light: Science & Applications (2025) https://doi.org/10.1101/2024.09.17.613468
H Chhajer and R Roy, "Rationalised experiment design for parameter estimation with sensitivity clustering" Scientific Reports (2024)
V Hill, et al., "A new lineage nomenclature to aid genomic surveillance of dengue virus" PLoS Biology (2024)
J Panwar and R Roy, "Modified capillary number to standardize droplet generation in suction driven microfluidics" Microfluidics and Nanofluidics (2024)
Rohit presented his thesis work on bacterial phenotupic heterogeneity at the MBU Colloquium. (07/2024)
Nanobiology Lab congratulates three newly minted PhDs. Drs. Suraj Jagtap, Harsh Chhajer and Ratnasri K receive their PhD degrees at the IISc Convocation 2024!
Rahul started his sabbatical at EPFL Lausanne. He will be working with Matteo Dal Peraro Lab on biological nanopores and developing new single molecule methods. (09/2023)
Suraj successfully defended his thesis on 'Understanding the interplay between immune response and virus evolution'. (09/2023)
Ankush joins the lab as PhD student, through Interdisciplinary Bioengineering program. (08/2023)
Ratnasri described how heterogeneity in bacterial population can give rise to diverse outcomes that critical for biotechnology and antimicrobial action in her BioEng thesis colloquium. (07/2023)
Harsh presented his thesis colloquium on 'Integrating Computational Tools and Models to Study RNA Virus Lifecycle Dynamics'. (04/2023)
Contact
rahulroy [at] iisc.ac.in / lakshmi [at] iisc.ac.in
to get more information on the lab
NanoBiology Lab
Department of Chemical Engineering
Indian Institute of Science
Bengaluru, Karnataka
560012
Phone: 91-80-2293-3115/8
Fax: 91-80-2360-8121
Email: rahulroy [at] iisc.ac.in / lakshmi [at] iisc.ac.in