Laboratory for NanoBiology

Our understanding of most biological processes comes from ensemble studies of the molecules carried out in a tube or using reporters in cells and organisms. Such mechanistic understanding of biological phenomena is complicated by

  • the heterogeneity among biomolecules (due to modifications or conformational dynamics) ,

  • the transient nature of interactions (activating action of molecule maybe limited to a fraction of its lifetime) and

  • the limits on detection of small number of molecules.

How do events taking place at the level of single molecule translate to biologically significant phenomena?

Our lab leads an interdisciplinary research program that aims to innovate and engineer technologies to help understand this basic question. We primarily focus on long-standing questions in infectious diseases caused by positive strand RNA viruses and pathogenic bacteria using single molecule detection, quantitative genomics and high-resolution imaging.

Such understanding of pathogen biology and host-pathogen interactions will help us design new drugs, vaccines and intervention strategies against several infectious diseases including Dengue.

To learn more, please read our research interests.

Our laboratory is located in the Department of Chemical Engineering at the Indian Institute of Science, Bangalore, India. We are also associated with the Centre for BioSystems Science and Engineering at IISc. Directions to the lab can be found here.

Latest Lab News

  • Saranya M presented her thesis colloquium on 'Quantitative sequencing of single RNA virus variants'. (06/2021)

  • Debdyuti Nandy joins our team as a Post-Doctoral fellow (04/2021). She joins us after completing her PhD from IICB/Univ of Calcutta.

  • Achinta Sannigrahi is selected for the prestigious SERB National Post-Doctoral fellowship (01/2021) Congratulations!!

Latest Publications and Preprints

  • Preprint of our joint work with Ganapathy Ayappa's lab on PFT conformational flexibility is now online (10/2021)

  • Our SARS-CoV2 serology assay is now published in Journal of Virological Methods (07/2021) Congratulations to the team!!

  • Harsh's preprint on viral life cycle dynamics of positive sense RNA viruses is online: BioRxiv (09/2020); now published in Journal of the Royal Society Interface (10/2021)

  • Vaseef's preprint on JE virus ribosome profiling that describes so many new tricks that the virus uses during translation of its proteome is out in BioRxiv (07/2020)

Last Major Updated: 17th March 2019