Laboratory for NanoBiology

Our understanding of most biological processes comes from ensemble studies of the molecules carried out in a tube or using reporters in cells and organisms. Such mechanistic understanding of biological phenomena is complicated by

  • the heterogeneity among biomolecules (due to modifications or conformational dynamics) ,
  • the transient nature of interactions (activating action of molecule maybe limited to a fraction of its lifetime) and
  • the limits on detection of small number of molecules.

How do events taking place at the level of single molecule translate to biologically significant phenomena?

Our lab leads an interdisciplinary research program that aims to innovate and engineer technologies to help understand this basic question. We primarily focus on long-standing questions in infectious diseases caused by positive strand RNA viruses and pathogenic bacteria using single molecule detection, quantitative genomics and high-resolution imaging.

To learn more, please read our research interests.

Our laboratory is located in the Department of Chemical Engineering at the Indian Institute of Science, Bangalore, India. We are also associated with the Molecular Biophysics Unit and the Centre for BioSystems Science and Engineering at IISc. Directions to the lab can be found here.

Latest News

  • Our joint work with Ayappa Lab and Visweswariah Lab on pore-forming toxin, Cytolysin A is online in PNAS (07/2018)
  • Harsh Chajjer is selected for the prestigious Prime Minister's Research Fellowship 2018 (05/2018)
  • Narendra and Subhasish's immunologic model to explain EOT+/SVR is accepted in Immunology and Cell Biology. Kudos to Subhasish! (04/2018)
  • Thrombin aptamer based detection using PIFE by Saurabh is published in Sensors and Actuators: Chemical. Congrats! (04/2018)
  • Our review on 'Single molecule Virology' for Journal of Biosciences is in press. Terrific work by Sunaina and Satya. (03/2018)
  • We file patent for a new method for quantification of biomolecules. Great ideas from Jatin and Priyanka. IPA #201841012166 (03/2018)
  • Jatin's first manuscript on fusible microelectrodes based impedance cytometry is on bioRxiv (03/2018)