CH 205 (JAN) 3:0
Chemical Reaction Engineering

Overview, review of background material. Differential and integral balances for homogeneous reactive systems. Ideal reactors: batch/CSTR/PFR. Uniqueness and multiplicity of steady states, heterogeneous reactions and reactors, non-ideal reactors.

Instructors: K Kesava Rao / Rahul Roy
Aris R., Elementary Chemical Reactor Analysis, Prentice-Hall 1969.
Schmidt, L.D., The Engineering of Chemical Reaction, Oxford, 1998.
Froment G.F., Bischoff K.B., and Wilde, J.D., Chemical Reactor Analysis and Design, Wiley, 2011.

CH 248 (JAN) 3:0
Molecular Systems Biology 

Various topics highlighting experimental techniques and modeling approaches in systems biology for problems ranging from molecular level to the multi-cellular level will be covered.

Topics: Properties of biomolecules, Biomolecular Forces, Single molecule experimental techniques, Molecular motors, Molecular heterogeneity, Self-organization, Enzyme kinetics, Modeling cellular reactions and processes, Fluctuations and noise in biology, Cellular variability, Biological networks, Modeling dynamics of bioprocesses and cellular signaling.

Rahul Roy

Course Notes:
The course is intended for Masters and PhD students. Undergraduates with sufficient background may approach the instructor regarding the course.
No prior knowledge of biology is needed but a non-biologist will have to self-educate.
Basic grasp of calculus, algebra and programming skills in C, Matlab or Mathematica is recommended.

Philip Nelson, Biological Physics: Energy, Information, Life, W. H. Freeman, 2007, ISBN-13: 978-0716798972.
Edda Klipp, Wolfram Liebermeister, Christoph Wierling, Axel Kowald, Hans Lehrach, Ralf Herwig, Systems Biology, Wiley-Vch, 2009, ISBN: 978-3527318742.
Uri Alon, An Introduction to Systems Biology: Design Principles of Biological Circuits, Chapman & Hall/CRC Mathematical & Computational Biology, 2006, ISBN: 978-1584886426.

MB 207 (AUG) 2:0
DNA-Protein interaction, Regulation of gene expression, Nanobiology

Basic concepts on structural basis for macromolecular recognition. Concept of charge in
macromolecules, specific and non-specific recognition, symmetry in DNA-protein recognition,
structural ensembles, co-operativity, specific examples, story of lambda, restriction enzyme
recognition, t-RNA synthetase recognition, promoter-RNA polymerase interaction, inducers and
repressors, action at a distance. Single molecule paradigm. Methods to follow nanobiology. DNA-protein
recognition at the level of single molecules.

Instructor: Dipankar Chatterji / Rahul Roy

CH 249 (JAN) 3:0
Structural and Functional DNA Nanotechnology

Origin of structural DNA nanotechnology; properties of DNA and other nucleic acids relevant to nanotechnology; design of branched DNA systems; DNA nanomechanical devices; DNA origami and DNA bricks; Forces and energetics in nanoscale; Thermodynamics of self-assembly formation; Experimental techniques to characterize DNA nanostructures including AFM; SEM; TEM; single molecule and bulk fluorescence; gel electrophoresis; sequencing and radio-labelling assays; Application of DNA nanostructures in molecular computing; organizing and templating other nanomaterials; bio-sensing; nano-fabrication; cargo delivery; hybrid DNA nanomaterials. 

Instructor: Banani Chakraborty/ Rahul Roy
DNA Nanotechnology: From structure to function /Fan, Chunhai /Springer
Structural DNA nanotechnology / Seeman, Nadrian / Cambridge Uni. Press
Articles / lecture notes provided by the instructor