Laboratory for NanoBiology

Biology at the Nanometer Level

Biology, as we know it, is the culmination of many singular events like the generation of ‘a’ mRNA from ‘a’ DNA by ‘a’ RNA polymerase. Yet, our understanding of most biological processes comes from ensemble studies of the molecules carried out in a tube or using reporters in cells and organisms. Mechanistic understanding of biological phenomena is complicated by
  • the heterogeneity among biomolecules (due to modifications or conformational dynamics) ,
  • the transient nature of interactions (activating action of molecule maybe limited to a fraction of its lifetime) and
  • the limits on detection of small number of molecules. 
How do events taking place at the level of single molecule translate to biologically significant phenomena?

Our lab leads an interdisciplinary research program that aims to innovate and engineer technologies to help understand this basic question. We primarily focus on long-standing questions in infectious diseases caused by positive strand RNA viruses and pathogenic bacteria using single molecule detection, quantitative genomics and high-resolution imaging.

To learn more, please read our research interests.

Our laboratory is located in the Department of Chemical Engineering at the Indian Institute of Science, Bangalore, India.
We are also associated with the Molecular Biophysics Unit and the Centre for BioSystems Science and Engineering at IISc. Directions to the lab can be found here.